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We examined three potential mechanisms of DHEAS action—sex hormone sufficiency, inflammatory status, and glucose regulation.

The relationship between DHEAS and cognition is complex and differs by sex and cognitive domain.

Physically inactive individuals with severe/morbid obesity had the most adverse clustered cardiometabolic risk profile.

Correspondence concerning this article should be addressed to Kerry L.

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Severe/morbid obese men are more affected than women regarding their cardiometabolic profile, although women presented higher inflammation.Higher DHEAS levels may be associated with better cognitive performance, although potential mechanisms for this relationship are not well established.We performed a cross-sectional study of the relationship between serum DHEAS and three aspects of cognition—executive function, working memory, and processing speed—in 49 men and 54 women, aged 60–88 years, with low serum DHEAS levels.We categorized participants as grade I (BMI 30–34.99) and grade II/III (BMI ≥ 35) obese.We measured markers of lipid and glucose metabolism, inflammation (high sensitivity C-reactive protein [hs-CRP]) blood pressure and renal function, as well as self-reported physical activity.

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